I was ready. I was so ready. I had all my chargers and AV adapters. My presentation was backed up on a USB drive. I had every talk I wanted to go to on my calendar. I had sent emails to professors I wanted to meet and network with. I reached out to friends I only see in March in a different city every year. It was 10 pm on Saturday, February 29. My flight to Denver was leaving at 6 am in the morning. Then the email arrived —
Our bodies are made up of cells that can sense and respond to their dynamic environment. As an example, pancreatic beta cells chemically sense increased blood sugar concentrations and respond by producing insulin. Scientists have found that cells can also mechanically sense their environment; “mechanosensing” determines whether a cell should grow or die. Cancer is characterized by uncontrolled cellular growth, where cells often contain mutations that inhibit the natural mechanisms of cell death. Because mechanosensing is one such mechanism, scientists have hypothesized that cancer cells keep growing because they lack the ability to probe their environments. In this week’s paper, published in Nature Materials, an international research team led by Bo Yang and Michael Sheetz from the National University of Singapore investigated that hypothesis by combining tools from soft matter physics and biology.
Recently, Nicholas Charles and researchers from Harvard published a study that used simulations of elastic fibers to probe their response to stretching and rotation applied simultaneously. The results shed light on how DNA, proteins, and other fibrous materials respond to forces and get their intricate shapes.