Imagine yourself as a small fly called a midge (shown in Figure 1a). You used to live in a lake as a small larva with no concerns in life except swimming, eating, and growing. One day, you hid underwater and formed a cocoon around your body as it developed wings, legs, and antennae. A few days later, you swam to the surface and burst out of your cocoon as an adult fly — a male. As a new adult male, you find the clock ticking – you have only a few days to find a mate before you die.
If we could shrink a submarine down to the microscopic scale, could we pilot it into the human body to fight infection and perform surgery? Despite suggestions from futuristic sci-fi such as “Fantastic Voyage”, “Honey, I Shrunk the Kids”, “The Magic School Bus”, “Power Rangers”, and “Rick and Morty”, we cannot survive such shrinking and our vessel would be without a pilot. But it may still be possible to “shrink” down some of our technology and control it remotely as we will see from researchers at MIT in this week’s paper.
If you just landed on Softbites for the first time, you probably have not had the chance to read our previous posts about microfluidics (like this one, or that one, and more). If this field of science is foreign to you, all you need to know is that it studies how fluids flow at really small scales (typically tens to hundreds of micrometers). For instance, you can quickly generate tiny droplets of a solution, turning each droplet into an individual “reactor”. Or you can create microenvironments with precisely controlled chemical concentrations to grow cells in different conditions.