Scientists often draw inspiration from biological organisms to describe phenomena, even when they are studying outside the realm of biology. Physicist Pierre-Gilles de Gennes was no exception. In 1971, after being inspired by the movement of snakes, he proposed reptation theory, or the reptation model, which has since been widely used to describe motions of polymers. As the name “reptation” suggests, de Gennes assumed polymer chains move like snakes. As shown in Figure 1, the model describes a polymer chain’s motion in an environment that is highly populated by other chains (shown in gray) by assuming that the chain is confined in a virtual tube (shown in red) formed by surrounding polymer chains. According to reptation theory, the chain wiggles through this tube, similar to a snake slithering through the woods. As one might imagine, directly imaging the snake-like slithering of polymers is a challenging affair; however, in today’s study, Maram Abadi and coworkers from King Abdullah University of Science and Technology were able to do just that with DNA chains – an example of a polymer – and compared their results to prevailing theory.