Discovery of Liquid Crystals in Short DNA

Ever since its discovery, scientists have known that the DNA molecule is present in every life form. It carries the genetic information of all living organisms and many viruses. Today, however, we will strip DNA of its genetic importance and look at it from a different perspective. We will discuss why DNA attracts attention even outside of the biological context: What is the connection between DNA and liquid crystals? What are end-to-end stacking interactions and why are they important? If you want to get answers on these questions (and many more), keep reading.

Knotty DNA

Try taking out your earphones from your pocket and, in all probability, you’ll find knots and entanglements between the ends. As it turns out, this knotting effect is not limited to macroscopic objects, but occurs on the nanoscale as well. A DNA molecule that carries the genetic information of a living organism is actually a long string-like polymer, so you can imagine that it would also get tangled up just like the cords of your earphones. In today’s paper, Calin Plesa and his colleagues at TU Delft are able to observe and measure these knots in DNA strands and uncover behaviour which has not been observed before.